Process for the preparation of 1-hydroxy-2-pyridones

Details Process for the preparation of 1-hydroxy-2-pyridones Process for the preparation of 1-hydroxy-2-pyridones

1995-11-02

1998-05-26

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546290, C07D21308

Patent

active

057567492

ABSTRACT:
The invention relates to a process for the preparation of 1-hydroxy-2-pyridones of the formula I ##STR1## by reaction of a pyrone of the formula II ##STR2## with a hydroxylammonium salt in the presence of basic compounds, which comprises carrying out the reaction in the presence of a distillable, filterable or extractable acid or a salt thereof in an amount of 0.01 to 20 equivalents with respect to the pyrone of the formula II, and employing as the basic compounds an alkali metal carbonate and/or alkali metal bicarbonate in an amount of 0.8 to 5 equivalents with respect to the hydroxylammonium salt, the radicals R.sup.1 and R.sup.2 in the formulae I and II are described herein.

REFERENCES:
patent: 3972888 (1976-08-01), Lohaus et al.
patent: 4797409 (1989-01-01), Lohaus et al.
patent: 4916228 (1990-04-01), Reuschling et al.
patent: 5286867 (1994-02-01), Lohaus et al.
El-Kholy, I.E. et al, J. Chem. Soc. (London). 1961, pp. 4490-4498.
Wiley, R.H. et al, J. Am. Chem. Soc. 1956, vol. 78, pp. 2393-2398.
March, J., Advanced Organic Chemistry: Reactions, Mechanisms and Structure, 1992, 4th edition, Wiley & Sons, Inc., pp. 421-424.

Affiliated with

Also associated with

Rating

Process for the preparation of 1-hydroxy-2-pyridones does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 1-hydroxy-2-pyridones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 1-hydroxy-2-pyridones will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1962144