Process for the preparation of 1-halo-3-trialkysilanyl-benzene d

Details Process for the preparation of 1-halo-3-trialkysilanyl-benzene d Process for the preparation of 1-halo-3-trialkysilanyl-benzene d

1994-11-08

1996-01-23

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

C07F 708

Patent

active

054866383

ABSTRACT:
The present invention relates to a novel process for preparing 1-halo-3-trialkylsilanyl-benzenes from 1,3-dihalo-benzenes which are useful intermediates in the preparation of 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones which are useful for the treatment of Alzheimer's disease and senile dementia.

REFERENCES:
patent: 3080324 (1963-03-01), Richards et al.
patent: 3347897 (1967-10-01), Webster
patent: 4116993 (1978-09-01), Bluestein et al.
Ramsden, Hugh E. et al., J. Org. Chem., vol. 22, pp. 1202-1206 (1957).
Chen, J. G. and Tamborski, J. Organometallic Chemistry, vol. 251, pp. 149-158 (1983).
Odabashyan, G. V. et al., Chemical Abstracts vol. 76, p. 478, 153843W, (1972).

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