Process for the preparation of 1-(aminomethyl)...

Details Process for the preparation of 1-(aminomethyl)... Process for the preparation of 1-(aminomethyl)...

2006-07-04

2006-07-04

Barts, Samuel (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

Reexamination Certificate

active

07071356

ABSTRACT:
A method of producing gabapentin (1-amino-methyl)-1-cyclohexaneacetic acid) from its hydrochloric salt in an anhydrous medium, the method consisting of:dissolving gabapentin hydrochloride in a non-aqueous organic solvent in which gabapentin is insoluble to obtain a solution of gabapentin hydrochloride;adding an epoxide to the solution to remove the chloride ions thereby precipitating gabapentin out of the solution as a white solid;recovering the white solid by filtration; anddrying the white solid.

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patent: 2004/0034248 (2004-02-01), Bercovici et al.
patent: 2005/0049432 (2005-03-01), Ferrari et al.
patent: WO 03/070683 (2003-08-01), None

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