Process for the preparation of 1 alpha,25-dihydroxylated vitamin

Details Process for the preparation of 1 alpha,25-dihydroxylated vitamin Process for the preparation of 1 alpha,25-dihydroxylated vitamin

1989-11-22

1991-07-30

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

549453, 540116, A61K 3159, C07J 900

Patent

active

050360612

ABSTRACT:
The present invention provides novel derivatives of vitamin D.sub.2 and more specifically 1 alpha,25-dihydroxylated compounds of the vitamin D series. A process for the preparation of such derivatives is also provided as are certain intermediates in such process.
The derivatives of this invention find ready application as substitutes for vitamin D.sub.3 or D.sub.2 or various of the known vitamin metabolites of these vitamins in their various applications to the correction of disorders involving calcium metabolism and associated bone disease.

REFERENCES:
patent: 4225596 (1980-09-01), DeLuca
patent: 4260549 (1981-04-01), DeLuca et al.
patent: 4267117 (1981-05-01), Salmond
patent: 4269777 (1981-05-01), DeLuca et al.
patent: 4448721 (1984-05-01), DeLuca et al.
Salmond et al, Tetrahedron Letters, No. 20, pp. 1695-1698, 1977.
Master's Thesis "Structure Function Relationships of Synthetic and Natural Analogs of Vitamin D" by Lorraine E. Reere, 1977, pp. 78-95.

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