Process for the preparation of 1-adamantane derivatives

Details Process for the preparation of 1-adamantane derivatives Process for the preparation of 1-adamantane derivatives

1989-09-06

1991-05-14

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

564 95, 568 62, 568634, 568732, 568733, 568737, C07C 6976

Patent

active

050157582

ABSTRACT:
A process for the preparation of 1-adamantane derivatives characterized by the fact that a 1-acyloxyadamantane, in which the acyl group contains 1 to 4 carbon atoms, is reacted with a receptor compound in a linear aliphatic or cycloaliphatic type solvent in the presence of concentrated sulfuric acid and at ambient temperature.

REFERENCES:
patent: 3883603 (1975-05-01), Inamoto et al.
patent: 4087410 (1978-05-01), Dominianni et al.
Journal of Medicinal Chemistry, vol. 18, No. 7, 1975, pp. 713-721, Washington, D.C., K. Aigami et al., "Biologically Active Polycycloalkanes". 1. Antiviral Adamantane Derivatives.

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