Process for the preparation of 1-[3-acetylthio-2(s)-methylpropan

Details Process for the preparation of 1-[3-acetylthio-2(s)-methylpropan Process for the preparation of 1-[3-acetylthio-2(s)-methylpropan

1994-06-13

1995-02-07

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20716

Patent

active

053876970

ABSTRACT:
The intermediate 1-[3-acetylthio-2(s)-methylpropanoyl]-1-proline is prepared by reacting L-proline with (R)-3-acetylthio-2-methyl propanoyl chloride at 0-5.degree. C., with pH controlled at 7.5-8.5, using 2.5M potassium hydroxide and potassium phosphate buffer, which gives >97% pure material after crystallizing from the reaction mixture.

REFERENCES:
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 5026873 (1991-06-01), Anderson et al.
patent: 5166361 (1992-11-01), Zepp
patent: 5276207 (1994-01-01), Schneider et al.

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