Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Reexamination Certificate
2000-03-29
2002-06-11
Padmanabhan, Sreeni (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
Reexamination Certificate
active
06403843
ABSTRACT:
The subject of the present invention is the heterogenous catalytic hydrogenation process, suitable for scaling up, for the synthesis of 1-(3,4-dimethoxyphenyl)ethanol (by other name &agr;-methylveratryl alcohol) of formula I. by the reduction of 3,4-dimethoxyacetophenone of formula II.
The title compound is the starting material to a number of important compounds and there is a growing demand for it. Among others, it can favourably be used for the preparation of the insecticide synergists described in WO 97/19040 and Hungarian patent applications No 3318/95 and 0893/97. Therefore, elaboration of an economical technology was required. It was necessary that the crude product obtained in the process be of high purity and not require purification operations, like for instance distillation. The 1-phenylethanols substituted with methoxy groups are namely surprisingly sensitive compounds and they can be purified only with substantial losses. On the effect of heat during the distillation, and/or on the effect of traces of acids or bases the above compounds readily transform into the bis-phenylethyl ethers of formula III (Chem. Pharm. Bull. 31, 3024 (1983); J. Chem. Soc. 3158 (1957); J. Am. Chem. Soc. 70, 1895 (1948)), or via dehydration they can form the styrene derivative of formula IV. (J. Am. Chem. Soc. 106, 1361 (1984)).
In the literature there are two basic methods for the synthesis of 1-(3,4-dimethoxyphenyl)ethanol. According to the first method the compound is prepared by the reaction of 3,4-dimethoxybenzaldehyde and methylmagnesium iodide (Chem. Pharm. Bull. 31, 3024 (1983)); according to the second by the reduction of 3′,4′-dimethoxyacetophenone (by other name acetoveratrone). The latter reduction can be performed by using sodium borohydride (Bull. Soc. Chim. France 1973 2667; J. Chem. Soc. Perkin 2 1994, 961; J. Am. Chem Soc. 86, 1186 (1964)), tributyltin hydride (J. Org. Chem. 59 7138 (1994)), sodium in ethanol (Arch. Pharm (Weinheim Ger.) 248, 139 (1910)), or aluminium isopropoxide (Ann. 1995, 677) in isopropanol. None of the above methods is suitable for large-scale technology, considering the costly reagents, the specific reaction conditions (eg. anhydrous solvents), the resulting waste materials, as well as the complicated work-up and purification procedures.
There is no reference in the literature for the heterogeneous catalytic hydrogenation of the acetoveratrone of formula II. This is surprising, since this route seems to be the most economical for the preparation of the compound of formula I, in an industrial scale.
Hydrogenation of the carbonyl group requires active catalyst. For the reduction of acetophenones catalysts as platinum metals (platinum, palladium, rhodium, ruthenium, iridium) (Ann. 1924, 276; J. Org. Chem. 24, 1885 (1959); Bull. Chem. Soc. Jpn. 34, 32 (1961)), nickel (J. Am. Chem Soc. 52, 4349 (1930); J. Org. Chem. 45, 1937, 1946 (1980)), Raney-nickel (J. Am. Chem. Soc. 70, 695 (1948); J. Chem. Soc. 3158 (1957); Ann. 714, 91 (1968); Bull. Soc. Chim. France 1972, 4324), or copper chromite (J. Am. Chem. Soc. 53, 1090 (1931)) may be used. The selectivity of these metals is, however, different. Rhodium catalyst is inclined to also saturate the ring, platinum, depending on the solvent and the pH, may cause hydrogenolysis, i.e the ethylbenzene by-product of formula V, will appear. For the catalytic hydrogenation of acetophenones the literature suggests the use of 10% palladium-on charcoal catalyst (Paul Rylander, Catalytic Hydrogenation in Organic Synthesis; p103, Academic Press, 1979).
Our first experiments verified that the known methods cannot directly be used. Hydrogenation of the acetoveratrone of formula II, following the procedure suggested by the literature, using 10% palladium-on charcoal catalyst, under normal conditions (25° C., 1 atm), in methanol as solvent, did not lead to homogeneous product.. Beside the expected 1-(3,4-dimethoxyphenyl)ethanol a high amount of ethylveratrole was also formed. The hydrogenation of the keto group and the hydrolysis of the C—O bond of the product proceeded simultaneously, at comparable rate, and in addition a considerable amount of 1-(3,4-dimethoxyphenyl)ethyl methyl ether by-product was also isolated. The electron-donating alkoxy groups activate the benzylic carbon atom to nucleofilic substitution, thus the latter in the given environment, for instance on the surface of the catalyst may react with a nucleophilic partner, in our case with the solvent, i.e. alcohol, but it may even react with the product of the reduction, i.e. with the &agr;-methylveratryl alcohol. To all this is added the sensitivity of the desired &agr;-methylveratryl alcohol of formula I, which makes the accomplishment of the process even more difficult, and which also explains why hydrogenation was not used for the preparation of that compound.
The growing demand for the compound in question, as well as the inexpensive implementation of catalytic hydrogenations, inspired us, despite the above difficulties, to work out a hydrogenation process which is exempt from the above disadvantages, ie. which results the desired compound of formula I in higher yield, higher purity and more economically than the previous methods.
Although rarely, nickel and Raney-nickel are also used for the hydrogenation of phenones, the reactions being carried out mainly in ethanolic or methanolic medium. According to the relevent literature a successful reaction requires rather drastic conditions (Paul Rylander, Catalytic Hydrogenation in Organic Synthesis, p83, Academic Press, 1979). As a concequence, one can expect in these reactions as well, the appearance of the appropriate 1-phenylethyl ethyl or methyl ether. The formation of this by-product can theoretically be exluded if aqueous medium or neutral catalyst is applied. Even though, no example can be find in the literature for hydrogenation of the given group of compounds in aqueous medium. The reason for that may be that the starting material and the product as well are expected to be rather insoluble in water, their solvation does not proceed, while the surface of the catalyst is deactivated, due to the polar solvate layer. (Paul Rylander, Catalytic Hydrogenation in Organic Synthesis, p83, Academic Press, 1979), all of these will cause the slowing-down of the reduction, and in the light of the above, the formation of by-products. To investigate this point, we calculated the partition ratio of acetoveratrone. To our surprise, a rather low value (calculated 1 gP≅1.22, K(octanol, water)≅16) was obtained. This means that the material has a weak, hydrophilic character and a suitable polarity. By increasing the temperature this value may further be ameliorated, which means that there was a chance that the reaction can proceed and the by-product formation can be suppressed. Carrying out the hydrogenation at a temperature higher than the melting point of the starting material (50° C.), suitable dispersity and solvation equlibrium may be ensured by vigourous stirring of the melt in the aqueous medium. Our expectations have been proven by our experiments. We investigated the hydrogenation of acetoveratrone at 20-80° C., by using neutral Raney-nickel catalyst. After 5-48 hours full transformation and the formation of homogeneous product was observed. If the reaction was performed at 50-80° C., under 6-10 bar hydrogen pressure, full conversion was achieved in much shorter time, depending on the intensity of the stirring (700-1250 l/min) the reaction accomplished in 3-7 hours. The product was obtained from the reaction mixture following evaporation under reduced pressure. Yields were in each case over 98%. As shown by analytical investigation (GC, HPLC, VRK) starting from a raw material of over 98% purity the assay for the product was higher than 97%. Total amuont of the unreacted starting material and the ethylveratrole by-product was as little as about 0.5%. The high purity of the product is well shown by the phenomenon, that on standing it crystallized, although previously this compound was only known a
Aradi Matyas
Arvai Geza
Bertok Bela
Kuruczne Ribai Zsuzsanna
Szalay Erzsebet
Agro-Chemie
Birch & Stewart Kolasch & Birch, LLP
Padmanabhan Sreeni
Witherspoon Sikarl A.
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