Process for the preparation of 1-(2-tetrahydrofuryl)-5-fluoroura

Details Process for the preparation of 1-(2-tetrahydrofuryl)-5-fluoroura Process for the preparation of 1-(2-tetrahydrofuryl)-5-fluoroura

1976-12-10

1981-03-17

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D40504

Patent

active

042568854

ABSTRACT:
A process for efficiently preparing 1-(2-tetrahydrofuryl)-5-fluorouracil useful as an antitumor agent or an antiviral agent which comprises reacting 5-fluorouracil with 2,3-dihydrofuran. This reaction proceeds advantageously in the presence of a reaction accelerator such as a Lewis acid in a polar solvent such as pyridine.

REFERENCES:
patent: 3960864 (1976-06-01), Townsend et al.
patent: 4107162 (1978-08-01), Suzuki et al.
OLAH, Friedel-Crafts & Related Reactions, vol. 1, pp. 173-176, Pub. by Interscience, (1963).
Brossmer et al., Chemical Abstracts, vol. 78, (1973), 58343r.

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