Process for the preparation of 1,2,4-substituted imidazoles and

Details Process for the preparation of 1,2,4-substituted imidazoles and Process for the preparation of 1,2,4-substituted imidazoles and

1993-12-21

1995-01-03

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

546210, 5483355, C07D23356, C07D23364

Patent

active

053788478

ABSTRACT:
The invention provides a new and efficient process for preparing 2,4(5)-substituted or 1,2,4-substituted imidazole derivatives.
The invention also provides a process for preparing substituted aminoalkylimidazole derivatives, useful for the treatment of mammals having a variety of disease states, including stroke, epilepsy, hypertension, angina, migraine, arrhythmia, thrombosis, embolism, and the like.

REFERENCES:
patent: 4829065 (1989-05-01), Pascal et al.
patent: 5043447 (1991-08-01), Pascal et al.
Insertion Reactions of Diethylaluminum Derivatives, by T. Hirabayashi et al J. Organometallic. Chem. (1969), vol. 21, pp. 273-280.
Sur un Noveau Procede de Syntheses de Derives Imidazoliques, by Eloy et al., Eur. J. Med. Chem-Chimica Therapeutica, (1974), pp. 602-606.

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