Process for the preparation of 1,2,4-substituted imidazoles and

Details Process for the preparation of 1,2,4-substituted imidazoles and Process for the preparation of 1,2,4-substituted imidazoles and

1993-04-09

1994-03-22

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483351, 5483355, 5483411, 5483425, 5483431, 5483435, C07D23356, C07D23364

Patent

active

052966097

ABSTRACT:
The invention provides a new and efficient process for preparing 2,4(5)-substituted or 1,2,4-substituted imidazole derivatives.
The invention also provides a process for preparing substituted aminoalkylimidazole derivatives, useful for the treatment of mammals having a variety of disease states, including stroke, epilepsy, hypertension, angina, migraine, arrhythmia, thrombosis, embolism, and the like.
The invention also relates to novel aminoalkylimidazole compounds.

REFERENCES:
patent: 4829065 (1989-05-01), Pascal et al.
patent: 5043447 (1991-08-01), Pascal et al.
CA105(19):172406q Pd(CH.sub.3 CN) 4 (BF4)2-assisted . . . reaction, Hegedos et al., p. 743, 1986.
CA107(25):236598e Palladium . . . halo-1,3-azoles, Sakamoto et al., p. 779, 1987.
CA114(7):62007p Dehydrogenation . . . carbon, Amemiya et al., p. 681, 1991.
Insertion Reactions of Diethylaluminum Derivatives, by T. Hirabayashi et al., J. Organometallic. Chem. (1969), vol. 21, pp. 273-280.
Sur un Noveau Procede de Synthese Derives Imidazoliques, by Eloy et al., Eur. J. Med. Chem-Chimica Therapeutica, (1974), pp. 602-606.

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