Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1984-11-01
1986-11-18
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
530307, 530311, C07K 100
Patent
active
046237160
ABSTRACT:
Peptides, such as calcitonin, having two cysteine residues connected by a disulfide bond are prepared by a process which includes the step of cyclizing the cysteines at a pH of 8.5 to 9.0, and a concentration of 0.4 to 1.8 mg of peptide per ml of solution. These novel conditions produce rapid cyclization with an unforeseen improvement in yield.
REFERENCES:
patent: 3929758 (1975-12-01), Hughes et al.
patent: 4033940 (1977-07-01), Hughes et al.
patent: 4212795 (1980-07-01), Hughes et al.
Islam Mohammad A.
Stevenson David
Phillips Delbert R.
USV Pharmaceutical Corp.
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