Process for the preparation and purification of eplerenone

Details Process for the preparation and purification of eplerenone Process for the preparation and purification of eplerenone

2007-03-26

2010-12-14

Badio, Barbara P (Department: 1628)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07851619

ABSTRACT:
A process for the preparation and purification of Eplerenone is described wherein hydroxylated impurities are removed using a novel derivatization procedure.

REFERENCES:
patent: 4559332 (1985-12-01), Grob et al.
patent: 6887991 (2005-05-01), Ng et al.
patent: WO 01/42272 (2001-06-01), None
Rabasseda, et al., Drugs of the Future, (1999), 24(5), pp. 488-501.
Grob, et al., Helvetica Chimica Acta, (1997), vol. 80, pp. 566-585.

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