Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-08-15
2006-08-15
Jiang, Shaojia A. (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S021000, C536S053000, C204S157600, C204S157630
Reexamination Certificate
active
07091337
ABSTRACT:
The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of high-energy radiation in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and formic acid. The invention also relates to intermediate depolymerized heparin having a molecular weight of between 1,000 and 5,500, absorbance at 400 nm below 0.300 and ratio SO3−/COO−equal to or higher than in the starting heparin. The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by gel permeation for obtaining the desired molecular weight.
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Baquey C. et al., “ESR Study of Gamma-Irradiated Sodium Heparinate”Radiation Research, 70:82-90 (1997).
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Jooyandeh F. et al., “Chemical Effects of Gamma-Irradiation of Aqueous Solutions of Heparin and Keratan Sulphate”,Radiation Research, 45:455-461 (1971).
De Ambrosi Luigi
Gonella Sergio
Vismara Elena
Jiang Shaojia A.
Krishnan Ganapathy
Laboratori Derivati Organici S.p.A.
O'Brien David G.
Yankwich Leon R.
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