Process for the optical resolution of threo-2-hydroxy-3-(2'-amin

Details Process for the optical resolution of threo-2-hydroxy-3-(2'-amin Process for the optical resolution of threo-2-hydroxy-3-(2'-amin

1990-11-19

1993-02-02

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562401, 562402, 562431, C07C31928, C07B 5700

Patent

active

051839229

ABSTRACT:
The present invention relates to a process for the separation of the enantiomers of threo-2-hydroxy-3-(2'- aminophenylthio)-3-(4"-methoxyphenyl)-propionic acid, which is an important intermediate in the synthesis of pharmacologically active compounds, by means of the direct crystallization of the relevant cyclohexylaminic salt.
According to a preferred form of practical embodiment of the present invention, the optically pure acid is recovered as the hydrochloride of the corresponding methyl ester.

REFERENCES:
patent: 4931587 (1990-06-01), Piselli
patent: 4939295 (1990-07-01), Merli et al.

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