Process for the optical resolution and recycling of tomoxetine

Details Process for the optical resolution and recycling of tomoxetine Process for the optical resolution and recycling of tomoxetine

2008-01-08

2008-01-08

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S303000, C564S424000, C514S649000

Reexamination Certificate

active

11170379

ABSTRACT:
The present invention provides a process for the optical resolution of racemic tomoxetine under reaction conditions that improve reaction yields and optical purity. The invention also provides an epimerization process for the (S)-(+) enantiomer. The invention further provides the conversion of the enantiomer obtained from the optical resolution into atomoxetine or a pharmaceutically acceptable salt thereof.

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