Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1981-09-21
1983-09-20
Rosen, Sam
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424358, 426641, A61K 3564, A61K 4700, A23L 134
Patent
active
044056028
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a process for the preparation of a biologically active bee-product meant as food, containing vitalizing and regenerating substances, mainly amino-acids, hormones, vitamins and mineral salts. Use can also be made of the said process as described by the invention in order to obtain a bee-product employed as a most biologically active raw material in the apitherapeutic and cosmetic industry.
PRIOR ART
It is known that the food the nurse bees give to the three categories of individuals: queen bee, worker bee and drone, during the first days of their embryonic development, is of identical quality and is known as royal jelly which is a purely glandular secretion greatly influencing their entire later metamorphosis in the larval and pupal stages.
After a first three-day long post-embryonic stage the worker and drone larvae are offered a kind of food which is qualitativety different from the royal jelly, consisting of a nutritive mixture made of pollen, bee bread, honey and water (the worker develops from a fertilized egg and the drone from a non-fertilized one).
The larval stage of the drone lasts for 8 days, i.e. the eleventh day since the egg has been laid, when the cell is capped, the larva ceases to be fed from outside and the pupal stage starts and lasts for 11-12 days.
The differentiated feeding of the drone larvae in the larval stage leads, by the contribution of pollen, bee-bread and honey to an increase in the sugars and protein nutritive value of the substances contained in the cells of the drone larvae (Barac I et al. "Beebreeding", Editura Agrosilvica, Bucharest 1965 )
Research works concerning the determination of the chemical composition of bee larvae are also known (Dewey M. Caron, American Bee Journal, 1978, 389).
SUMMARY OF THE INVENTION
Taking into account the composition of the drone larvae, very rich in nutritive substances, the present invention aims at obtaining a biologically active product summing up all the nutritive substances contained in the body of the drone larvae and in the larval food contained in the comb cells from which the larvae are picked up.
Consequently, the said process, as described by the invention, provides for the trituration of the drone larvae picked up in the 10-th day since the non-fertilized egg has been laid, together with the whole content of the respective comb cells, homogenization and filtration of the triturate resulting in a "fresh product" and, when needed, the lyophilization of the mixture resulting in a "standard dehydrated product". Picking up, trituration and filtration are to be made under sterile conditions.
The fresh product, obtained as stated above, will be kept at temperatures ranging between -5.degree. to -15.degree. C.
This process can also be applied to queen bee larvae or to worker larvae, by modifying the date when larvae are picked up depending on the duration of individual metamorphosis e.g., a day before cell capping.
The physical and chemical characteristics of the larval triturate prior to lyophilisation are the following:
Aspect: viscous and homogeneousmass with a fine granulation
Colour: white with a tendency of greyish-brownish shading
Consistency: milky, unctuous, slightly viscous
Smell: characteristic of larval food, slightly flavoured
Taste: cream-like, slightly astringent without disagreeable sensations.
Impurities:
upon macroscopic analysis:
pieces of wax, untriturated larvae, epithelia, Varoa mites or any matters of a nature other than that of the product as described by the invention are not admitted.
upon microscopic analysis:
pieces of larvae or epithelia are not admitted. Isolated larval cells, pollen cells (maximum 1-30/microscopic field), yeasts (maximum 25/microscopic field) are admitted.
______________________________________ pH 4.8-6.7
moisture content %
65-80
dry matters content g %
20-35
proteins, total g %
10-20
sugars, total g % 1.00-5.50
lipids, total g % 5.00-6.30
ash g % 1.00-1.50
indeterminate 4.00-6.00
matters g %
min
REFERENCES:
Bordas-Chem. Abst. vol. 69, (1968), p. 109, 757c.
Cooperativa Agricola de Productie Scornicesti
Dubno Herbert
Rosen Sam
Ross Karl F.
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