Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1989-12-12
1992-11-17
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
4352521, C12P 718
Patent
active
051643090
ABSTRACT:
A process of the microbiological preparation of 1,3 propane diol from glycerol in growth media of suitable bacterial strains is described, accompanied by the addition of a cosubstrate in the form of a H-donor and the separation of the propane diol formed. It is characterized in that a) biomass is formed in a growth phase from the selected bacterial strain and accompanied by feeding with glycerol and, if necessary, while substantially excluding the H-donor until a stationary growth phase occurs and b) further glycerol and H-donor matched to the biomass are added to the resulting stationary cell suspension for increased 1,3-propane diol formation. This process makes it possible to produce 1,3-propane diol in a high yield from glycerol with a small amount of unobjectionable by-products in a batchwise manner or in continuous form, following immobilization.
REFERENCES:
Johnson et al., "Inactivation of Glycerol Dehydrogenase of Klebsiella pneumoniae and the Role of Divalent Cations", J. Bacteriology, vol. 164, No. 1, pp. 479-483, 1985.
Schutz et al., "Anaerobic Reduction of Glycerol to Propanediol-1.3 by Lactobacillus brevis and Lactobacillus buchneri", System. Appl. Microbiol. vol. 5, pp. 169-178, 1984.
Streekstra et al., "Overflow metabolism during anaerobic growth of Klebsiella aerogenes NCTC 418 on glycerol and dihydroxyacetone in chemostat culture", Arch. Microbiol., vol. 147, pp. 268-275, 1987.
Averhoff Beate
Gottschalk G.
Knode Marian C.
Robinson Douglas W.
Unilever Patent Holdings B.V.
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