Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2005-02-22
2005-02-22
Carlson, Karen Cochrane (Department: 1653)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S252320, C435S325000, C435S320100, C435S252300, C536S023700, C536S024100, C530S350000
Reexamination Certificate
active
06858406
ABSTRACT:
The invention pertains to a process for the microbial production of amino acids. The process involves boosting the export carrier activity and/or export gene expression of a microorganism which produces the desired amino acid. It was found that a single specific gene is responsible for the export of a given amino acid, and on that basis, a process for the microbial production of amino acids, involving the controlled boosting of the export gene expression and/or export carrier activity of a microorganism was developed, which produces the amino acid. The boosted expression or activity of the export carrier resulting from this process increases the secretion rate and thus increases transport of the desired amino acid.
REFERENCES:
Lodish et al. “Molecular Cell Biology”, Fourth edition, Publisher: W.H. Freeman & company, pp. 255-256, 1999.*
Vrljic et al. “Unbalance of L-Lysine flux inCorynebacterium glutamicumand its use for the isolation of excretion-defective mutants”, J. of Bacteriology, vol. 177 (4), Jul. 1995.*
Vrljic et al., “A new type of transporter with a new type of cellular function: L-lysine export fromCorynebacterium glutamicum”, 1996, Molecular Microbiology, vol. 22(5), pp. 815-826.*
Ayala et al., “Modern Genetics”, second edition, 1984, Glossary.
Eggeling Lothar
Sahm Hermann
Vrlijc Marina
Bach Klaus J.
Carlson Karen Cochrane
Forschungszentrum Jülich GmbH
Mitra Rita
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