Process for the membrane-filtering of protein solutions

Details Process for the membrane-filtering of protein solutions Process for the membrane-filtering of protein solutions

1994-01-07

1995-11-21

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Albumin

21032168, 210780, 530364, 530386, 5303901, 530414, 530427, 530832, 530833, B01D 2432, C07K 134, C07K 1447, C07K 1476

Patent

active

054688442

ABSTRACT:
An improvement is provided in a process for the membrane filtration of a protein solution. The improvement consists of applying a high shear force at the surface of the membrane. In embodiments of such process, the liquid is subjected to membrane filtration utilizing a rotating membrane disc mounted in close proximity e.g., about 1/8" to about 1/4" to a stationary solid disc, or a rotating solid disc mounted in close proximity e.g., about 1/8" to about 1/4" to a stationary membrane surface with the relative rotation being between bout 1,000 and about 3,450 RPM. This results in permeation characteristics of the selected membrane which essentially represents its theoretical molecular weight cut-off.

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