Process for the maturation of dendritic cells and a vaccine

Details Process for the maturation of dendritic cells and a vaccine Process for the maturation of dendritic cells and a vaccine

2011-07-19

2011-07-19

Long, Scott (Department: 1633)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

Reexamination Certificate

active

07981673

ABSTRACT:
The invention proves a method of producing mature dendritic cells in vitro, which comprises the step of culturing the immature dendritic cells in the presence of a specifically configured high molecular weight double stranded RNA (dsRNA) polymer. The specifically configured high molecular weight dsRNA polymer is typically selected from the group comprising poly[I]:poly [CxU]; poly [I]:poly [GxU]; poly [A]: poly [UxC]; poly [A]:poly [UxG]; poly [U]:poly [AxC]; poly [U]:poly [IxU]; poly [C]:poly [GxA]; poly [C]:poly [GxU]; poly [G]:poly [CxA]; poly [G]:poly [CxU] and AMPLIGEN® (poly[I]:poly[C12U]), where x is on average a number from 3 to 40. The immature dendritic cells may be exposed to an antigen before they are matured, and a vaccine including the antigen-presenting mature dendritic cells can then be prepared. A method of treating cancer, a virus, parasite and microorganism is also disclosed.

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