Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1997-03-24
1998-06-09
Kumar, Shailendra
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
424 9254, C07C23365
Patent
active
057636630
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/EP96/03150 filed Jul. 17, 1996.
This invention refers to a new synthetic process especially for the manufacturing of derivatives of diamides of 5-alkoxy-2,4,6-triiodo-1,3-benzenedicarboxylic acids of general formula (I) ##STR4## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, which can be the same or different are, independently, H or a linear or branched (C.sub.1 -C.sub.10) alkyl group, optionally substituted by 1-6 hydroxy and/or alkoxy groups, or a polyoxyalkyl group comprising from 1 to 10 oxygen atoms and from 3 to 30 carbon atoms, or R.sub.1 and R.sub.2 or R.sub.3 and R.sub.4, taken together, form a (C.sub.2 -C.sub.8) chain optionally interrupted by one or more N, O, S atoms; ##STR5## R.sub.6 and R.sub.8, which can be the same or different are, independently, H or a (C.sub.1 -C.sub.6) alkyl, hydroxyalkyl, alkoxyalkyl or alkoxyhydroxyalkyl group, group, ##STR6## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as previously described and the hydroxy group on the benzene ring can be also present as salt of an alkali metal or alkaline-earth metal or a (C.sub.2 -C.sub.6) trialkylamine, are reacted with the compounds of general formula (III) ##STR7## Z is halogen atom or a reactive residue of a sulfonic acid or a cation --N.sup.+ (R.sub.9).sub.3 wherein R.sub.9 is a (C.sub.1 -C.sub.6) alkyl group and
The preparation of the compounds of general formula (I) has been previously described in patent EP 185130, which describes the synthesis of the above compounds starting from phenol precursors or from their salts according to Scheme 1. ##STR8##
The above patent foresees the reaction of the phenol groups in the free form or the reaction in the salified form with alkali or alkaline-earth metals with a reactive compound R.sub.5 '--Z', preferably containing an alkoxycarbonylalkyl group and a reactive group Z', with the same meaning for Z in this invention and the successive transformation of the ester group into amido group, by reaction with ammonia or with differently substituted amines.
The resulting products of formula 2 can be useful also as intermediates as described in patent EP 365541, for the preparation of X-ray contrast media by Smiles rearrangement.
Differently from patent EP 185130, the process of this invention, foresees only one step for the production of the desired product, i.e. the direct reaction of phenol precursors with a reactive compound already containing the desired amido group, as from Scheme 2. ##STR9##
The use of an amido derivative in the reaction of nucleophilic substitution to give derivatives of general formula (I) instead of an ester derivative, as described in patent EP 185130, leads to a considerable decrease in the number of synthetic steps required to obtain the final compounds of general formula (II).
The application of the process of this invention is particularly interesting for the preparation of an intermediate in the synthesis of no!-2,4,6triiodo-1,3-benzenedicarboxamide, commonly known as IOPAMIDOL, which is one of the world best-seller in the field of non-ionic X-ray contrast media.
The synthesis method described in EP 365541, foresees the formation of intermediate 3, according to the procedure described in the already cited EP 185130, followed by Smiles rearrangement, as shown in Scheme 3. ##STR10##
A more straightforward preparation for iopamidol can be carried out by the sequence of reactions shown in Scheme 4 and described in Examples 1, 2 and 4. ##STR11##
More generally, in order to carry out the process of this invention, the salts of phenol derivatives of general formula (II) are particularly suitable for the reaction of etherification, in particular their sodium, potassium and calcium salts.
The reactive group Z in compounds of general formula (III) is as definition a halide Cl, Br and I, or a reactive residue of a sulfonic acid (for instance methanesulfonyloxy (MeSO.sub.2 O.sup.-), benzenesulfonyloxy (PhSO.sub.2 O.sup.-), nitrobenzenesulfonyloxy (p-NO.sub.2 PhSO.sub.2 O.sup.-), toluensulfonyloxy (TsO.sup.-), and so on), preferably t
REFERENCES:
Chemical Abstracts, vol. 66, No. 1m 2 Jan. 1967, Columbus, Ohio, US; abstract No. 2393, Cassebaum, Heinz et al; "Preparation of low toxicity triiodo contrasting agents for x-rays" XP002019517.
Anelli Lucio Pier
Brocchetta Marino
Gazzotti Ornella
Uggeri Fulvio
Dibra S.p.A.
Kumar Shailendra
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