Process for the manufacture of α-tocopheryl acetate

Details Process for the manufacture of α-tocopheryl acetate Process for the manufacture of α-tocopheryl acetate

2006-11-14

2006-11-14

Solola, Taofiq (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07135580

ABSTRACT:
The present invention is concerned with a novel process for the manufacture of α-tocopheryl acetate which comprises reacting 2,3,6-trimethylhydroquinone-1-acetate with a compound selected from the group consisting of phytol (formula IV with R═OH), iso-phytol (formula III with R═OH), and (iso) phytol derivatives represented by the following formulae III and IV with R═C2-to C5-alkonoyloxy, benzoyloxy, mesyloxy, bezenesul-fonyloxy or tosyloxy,(IV) in the presence of a catalyst of the formula Mn+(R1SO3−)n, wherein Mn+is a silver, copper, gallium, hafnium or rare earth metal cation, n is the valence of the cation Mn+, and R1is fluorine, C1-8-perfluoroalkyl or perfluoroaryl, and, if required, cyclizing any 3-phytyl-2,5,6-trimethylhydroquinone-1-acetate or a double bond isomer thereof obtained as an intermediate reaction product, to produce α-tocopheryl acetate. In the catalyst Mn+is preferably Ag+, Cu+, Ga3+, Sc3+, Lu3+, Ho3+, Tm3+, Yb3+or Hf4+.

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