Process for the manufacture of wholly microfabricated biosensors

Details Process for the manufacture of wholly microfabricated biosensors Process for the manufacture of wholly microfabricated biosensors

1993-08-19

1996-09-10

Jones, W. Gary

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

422 63, 422 681, 422 69, 422 78, 422 79, 422 8205, 435 6, 436501, 935 88, G01N 2100, G01N 2101, G01N 3000, C12M 100

Patent

active

055543391

ABSTRACT:
An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.

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