Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-07
1998-11-17
Chin, Christopher L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
204403, 204411, 204412, 204414, 204415, 204416, 204417, 204419, 422 57, 422 8208, 427 211, 427 213, 427 58, 427 96, 435 14, 435 25, 4352871, 4352872, 4352879, 435177, 435817, 436518, 436524, 436528, 436806, G01N 33543, G01N 33545
Patent
active
058374540
ABSTRACT:
An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.
REFERENCES:
patent: 5063081 (1991-11-01), Cozzette et al.
patent: 5417835 (1995-05-01), Brown et al.
patent: 5437973 (1995-08-01), Vadgama et al.
patent: 5466575 (1995-11-01), Cozzette et al.
patent: 5543024 (1996-08-01), Hanazato et al.
Cozzette Stephen N.
Davis Graham
Itak Jeanne
Lauks Imants R.
Mier, deceased Randall M.
Chin Christopher L.
i-STAT Corporation
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