Process for the manufacture of wholly microfabricated biosensors

Details Process for the manufacture of wholly microfabricated biosensors Process for the manufacture of wholly microfabricated biosensors

1995-06-07

1998-11-17

Chin, Christopher L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

204400, 204413, 204411, 204412, 422 57, 422 8208, 435 14, 435 25, 435177, 4352871, 4352872, 435817, 436149, 436150, 436151, 436518, 436528, 436531, 436532, 436806, G01N 3353, G01N 33543, G01N 3368

Patent

active

058374469

ABSTRACT:
An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over he dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.

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