Process for the manufacture of thioformamido-phosphono-acetates

Details Process for the manufacture of thioformamido-phosphono-acetates Process for the manufacture of thioformamido-phosphono-acetates

1975-08-28

1977-08-30

Raymond, Richard L.

Chemistry of carbon compounds

Dipeptides, e.g., aspartame, anserine, carnosine, etc.

260940, 260941, 260968, 260327R, 260327TH, 2603322R, 260333, 2603458R, 2603472, C07F 940

Patent

active

040455203

ABSTRACT:
Thioformamidophosphono-acetates are prepared by reacting an isocyano compound of the formula C=N--CH.sub.2 --X.sub.1 in the presence of a base with a compound of the formula R.sub.o --X.sub.2, in which compounds one of the groups X.sub.1 and X.sub.2 represents a protected carboxyl group of the formula --C(=O)--OR.sub.1 and the other a disubstituted phosphono group of the formula --P(.fwdarw.O)(OR).sub.2, and wherein R.sub.o represents a reactive etherified or esterified hydroxyl group, and adding hydrogen sulphide on to the isocyano group of the phosphono-isocyano-acetate formed as an intermediate.

REFERENCES:
patent: 2963458 (1960-12-01), Swern
patent: 3381061 (1968-04-01), Ratz et al.
patent: 3627842 (1971-12-01), Nicholson

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