Process for the manufacture of spiro-linked pyrrolidine-2,5-dion

Details Process for the manufacture of spiro-linked pyrrolidine-2,5-dion Process for the manufacture of spiro-linked pyrrolidine-2,5-dion

1987-07-10

1988-08-16

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 70, 546 15, C07D27910, C07D27301, C07D22100

Patent

active

047646080

ABSTRACT:
This invention relates to novel processes for the manufacture of spiro-linked pyrrolidine-2,5-diones of formula; ##STR1## which have a potent inhibitory activity on aldose reductase and are useful for reduction and prevention of chronic diabetic complications.
The invented processes are useful as improved and convenient method for a large scale manufacture.

REFERENCES:
patent: 4443465 (1984-04-01), Brittain et al.
patent: 4593092 (1986-06-01), Irikura et al.
Takagi et al. Chem. Abstracts, vol. 104, 5884s (1986).

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