Process for the manufacture of quinoline derivatives

Details Process for the manufacture of quinoline derivatives Process for the manufacture of quinoline derivatives

2005-04-05

2005-04-05

Raymond, Richard L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S155000

Reexamination Certificate

active

06875869

ABSTRACT:
A process for the preparation of the compounds of general formula (I)wherein R is selected from methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, sec.-butyl and allyl; R5is selected from the methyl, ethyl, n-propyl, iso-propyl, methoxy, ethoxy, methylthio, ethylthio, n-propylthio, methylsulphinyl, ethylsulphinyl, fluoro, chloro, bromo, trifluoromethyl, and OCHxFy; wherein x=0-2, y=1-3 with the proviso that x+y=3; R6is hydrogen; or R5and R6taken together are methylenedioxy; R′ is selected from methyl, methoxy, fluoro, chloro, bromo, trifluoromethyl, and OCHxFy, wherein x=0-2, y=1-3 with the proviso that x+y=3; R″ is selected form hydrogen, fluoro and chloro, with the proviso that R″ is selected from fluoro and chloro only when R′ is selected from fluoro and chloro; by reacting a quinoline-3-carboxylic acid ester derivative of formula A with an aniline derivative of formula Bin a solvent selected from straight or branched alkanes and cycloalkanes or mixtures thereof with a boiling point between 80 and 200° C.

REFERENCES:
patent: 4738971 (1988-04-01), Eriksoo et al.
patent: 5912349 (1999-06-01), Sih
patent: 6077851 (2000-06-01), Bjork et al.
patent: 6121287 (2000-09-01), Bjork et al.
patent: 6133285 (2000-10-01), Bjork et al.

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