Process for the manufacture of pyrimidine derivatives

Details Process for the manufacture of pyrimidine derivatives Process for the manufacture of pyrimidine derivatives

1974-08-27

1976-09-14

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424251, C07D23930, C07D23948

Patent

active

039806499

ABSTRACT:
A process for the manufacture of 2,4-diamino-5-(substituted benzyl)pyrimidines from the corresponding 6-hydroxy-derivatives or the hydrochloride thereof by (a) chlorinating with phosphoryl chloride in presence of a considerable excess of hydrogen chloride and (b) hydrogenation of the thus easily in practically pure form and with high yields obtained 6-chloro derivatives.

REFERENCES:
patent: 2433440 (1947-12-01), Curd et al.
patent: 3238208 (1966-03-01), Gerns et al.
patent: 3455923 (1969-01-01), Mizzoni et al.
patent: 3707560 (1972-12-01), De Angelis et al.

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