Process for the manufacture of p-hydroxybenzyl cyanide

Details Process for the manufacture of p-hydroxybenzyl cyanide Process for the manufacture of p-hydroxybenzyl cyanide

1978-05-22

1979-05-15

Brust, Joseph Paul

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260559R, C07C12000, C07C12166

Patent

active

041547578

ABSTRACT:
A process for the manufacture of p-hydroxybenzyl cyanide which comprises reacting p-hydroxymandelic acid with cyanide ion. The product is a useful intermediate for the preparation of the .beta.-adrenergic blocking agent atenolol.

REFERENCES:
patent: 3983151 (1976-09-01), Meyer
patent: 3983160 (1976-09-01), Meyer
C.A., 82, (1975), Hayashi et al., 124965f.
C.A., 85, (1976), Schwartz et al., 46160k.
C.A., 85, (1976), Meyer, 46229q.

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