Process for the manufacture of p-hydroxybenzyl cyanide

Details Process for the manufacture of p-hydroxybenzyl cyanide Process for the manufacture of p-hydroxybenzyl cyanide

1981-04-13

1982-03-02

Torrence, Dolph H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C12006, C07C12175

Patent

active

043177816

ABSTRACT:
An improved process for the preparation of p-hydroxybenzyl cyanide by the reaction of p-hydroxybenzyl alcohol with an alkali metal cyanide, by carrying out the process in the presence of an alkyl formate, especially n-propyl formate. The cyanide product is a valuable intermediate for the preparation of the .beta.-adrenergic blocking agent atenolol.

REFERENCES:
patent: 3983160 (1976-09-01), Merger
patent: 4154758 (1979-05-01), McMenim
Schwartz, et al., J. Org. Chem., vol. 41, No. 14, pp. 2502-2503 (1976).

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