Process for the manufacture of N-substituted indoles

Details Process for the manufacture of N-substituted indoles Process for the manufacture of N-substituted indoles

1975-05-12

1977-05-10

Love, Ethel G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D20904, C07D20910

Patent

active

040228029

ABSTRACT:
A process for the manufacture of N-substituted indoles, wherein an indole is treated with a base in dimethyl sulphoxide, or in a dipolar aprotic solvent with a tertiary acid amide group, such as dimethyl formamide, and subsequently reacted with an alkylating or aralkylating agent and the new indoles carrying in the 1-position an alkyl radical with at least 6 carbon atoms or an alkenyl radical with at least 3 carbon atoms, or an alkyl or alkenyl radical which is substituted with halogen, a hydroxy, cyano, carboxy, lower alkoxy, alkylamino or alkoxycarbonyl group.

REFERENCES:
patent: 3478208 (1969-11-01), Horrocks et al.
Hobbs et al., "J.A.C.S.", vol. 84, pp. 45 and 49 (1962).

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