Process for the manufacture of (midazolam)

Details Process for the manufacture of (midazolam) Process for the manufacture of (midazolam)

1997-08-26

1998-08-11

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20404

Patent

active

057928746

ABSTRACT:
A multistep process for producing (midazolam) comprises treating a compound of Formula II with a lower alkyl dithiol to produce a compound of Formula III, wherein n=2 or 3, converting the compound of Formula III to a compound of Formula VII, and then treating the compound of Formula VII with a deprotecting agent, thereby producing midazolam. Novel intermediate compounds are also disclosed.

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Raasch et al., (J. Org. Chem., vol. 35(10), pp. 3470-83, 1970).
Stahl et al., (Chem. Ber., vol. 120(2), pp. 135-139, 1987).
Ramig et al., Tetrahederon Letters, vol. 33, No. 42, pp. 6279-6282, 1992).
Walser et al., J. Het. Chem., vol. 20(3), pp. 551-558, 1983).
Walser et al., J. Org. Chem., vol. 43(5), pp. 936-944, 1978).
Freyer et al., J. Org. Chem., vol. 43(23), pp. 4480-4444, 1978).

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