Process for the manufacture of LH-RH and LH-RH analogs using Glu

Details Process for the manufacture of LH-RH and LH-RH analogs using Glu Process for the manufacture of LH-RH and LH-RH analogs using Glu

1980-02-12

1981-06-23

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, C07C10352

Patent

active

042750016

ABSTRACT:
What is disclosed is a method for the manufacture of LH-RH and LH-RH analogs, which comprises reacting Glu-His(DnP)-OH with the corresponding peptide having a free amino group and protected carboxy groups in a solvent as used in peptide chemistry and with the addition of 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine (HOObt) and a carbodiimide and then splitting off the Dnp-(2,4-dinitrophenyl) group. The new method greatly reduces the degree of histidine racemization. The invention also provides a new dipeptide, i.e. Glu-His(Dnp)-OH.

REFERENCES:
patent: 4083967 (1978-04-01), Beddell et al.

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