Process for the manufacture of iohexol

Details Process for the manufacture of iohexol Process for the manufacture of iohexol

2006-03-03

2009-06-02

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C424S009452

Reexamination Certificate

active

07541494

ABSTRACT:
A process for the production of iohexol comprises alkylating 5-Acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide using 2(2-methoxy-ethoxy)-ethanol as solvent in the presence of a base, and optionally isolating crude iohexol from the reaction mixture. Preferably, the alkylating agent is 1-chloro-2,3 propanediol and the base is an alkali metal hydroxide such as sodium hydroxide or potassium hydroxide.

REFERENCES:
patent: 4250113 (1981-02-01), Nordal et al.
patent: 6469208 (2002-10-01), Villax et al.
patent: 6897339 (2005-05-01), Turchetta et al.
patent: 9808804 (1998-03-01), None
patent: 2005003080 (2005-01-01), None
Foreign communication from the priority application—International Search Report and Written Opinion, PCT/GB2006/000768, May 3, 2006, 8 pages.

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