Process for the manufacture of indole derivatives

Details Process for the manufacture of indole derivatives Process for the manufacture of indole derivatives

1976-04-22

1977-05-10

Schenkman, Leonard

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602565R, C07D23972

Patent

active

040227804

ABSTRACT:
Manufacture of 1-(quinazolin-4-yl)indol-3-ylacetic acids and salts thereof by reacting a phenylhydrazone derivative with a quinazoline derivative, for example a halogenoquinazoline, and then ring-closing the resulting intermediate product. An illustrative product of the process of the invention is 1-(7-chloroquinazolin-4-yl)-5-methoxy-2-methylindol-3-ylacetic acid.

REFERENCES:
patent: 3190889 (1965-06-01), Shen
patent: 3833587 (1974-09-01), Gabel
patent: 3884919 (1975-05-01), Birchall et al.

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