Process for the manufacture of hydroxylated isoflavones

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C568S322000, C568S331000

Reexamination Certificate

active

07820836

ABSTRACT:
A process for the preparation of hydroxylated isoflavones by reacting in a Hoesch reaction using an alkanoic acid alkyl ester as solvent a phenol with a phenylacetonitrile to yield a 1,2-diphenyl-ethanone and transforming the ethanone into an isoflavone by well-known methods.

REFERENCES:
patent: WO 2004/009576 (2004-01-01), None
Chang et al, “Microwave-Mediated synthesis of Anticarcinogenic Isoflavones from Soybeans”, Journal of Agricultural and Food Chemistry, vol. 42, No. 9, 1994, pp. 1869-1871.
Ferro et al, “Synthesis of New Potential HIV-1 Integrase Inhibitors”, Heterocycles, vol. 63, No. 12, Dec. 1, 2004, pp. 2727-2734.
Houben et al, “Uber die Kernkondensation von Phenolen und Phenol-athern mit Nitrilen zu Phenol—Ketonen. II.: Synthese mit anisol, o-Brom-anisol, Phenotol, o-, m- und p-Kresylathern, Veratrol und Resorcin-ather” Chemische Berichte, vol. 60, No. 8, Sep. 21, 1927, pp. 1759-1778.
International Search Report mailed Jul. 24, 2006 in PCT/EP2006/003252.
Written Opinion mailed Jul. 24, 2006 in PCT/EP2006/003252.

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