Process for the manufacture of enol derivatives

Details Process for the manufacture of enol derivatives Process for the manufacture of enol derivatives

1982-09-30

1985-10-29

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 22, 544 25, 544 27, 260239A, C07D50102, A61K 31545, C07D50138

Patent

active

045501629

ABSTRACT:
The invention concerns a process for the manufacture of 7.beta.-amino-3-cephem-3-ol-4-carboxylic acid compounds by ring closure of esters of 2-[4-(substituted-thio)-3-acylamino-2-oxoazetidin-1-yl]-3-substituted-amin o-crotonic acids and solvolysing the enamine group in the resulting 7.beta.-acylamino-3-substituted-amino-cephem-4-carboxylic acid esters.

REFERENCES:
patent: 4013651 (1977-03-01), Spitzer
patent: 4036835 (1977-07-01), Foglio et al.
patent: 4052408 (1977-10-01), Heusle et al.
patent: 4065618 (1977-12-01), Spitzer
patent: 4066641 (1978-01-01), Hamashima et al.
patent: 4079181 (1980-07-01), Tsuji et at.
patent: 4147864 (1979-04-01), Woodward et al.
patent: 4160085 (1979-07-01), Tsuji et al.

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