Process for the manufacture of dihydropyrimidines

Details Process for the manufacture of dihydropyrimidines Process for the manufacture of dihydropyrimidines

1994-12-23

1996-11-19

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544252, 544254, 544255, 544256, 544282, 544356, 546159, 546180, 548121, 548152, 548161, 548190, 548217, 548221, 548222, 548233, 548235, 5483074, 548483, 564383, 564509, C07D49804, C07D51304, C07D51704

Patent

active

055764320

ABSTRACT:
A process of preparing a dihydropyrimidine compound of the structure (I): ##STR1## wherein R.sup.1 and R.sup.2 are bonded together to form an aromatic or heterocyclic ring, which may be substituted or unsubstituted, or are individually selected from the group consisting of hydrogen, or a substituted or unsubstituted aliphatic, carbocyclic, or heterocyclic group;

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patent: 4471117 (1984-09-01), Sipido
patent: 5192654 (1993-03-01), Hioki et al.
Engel et al, Chemical Abstracts, vol. 108, No. 56121.
Lutz, Chemical Reviews, vol. 84 pp. 205-247 (1984).
Richardson Fused Pyrimidines as Potential Antimicrobic Agents Journal of Medicinal Chemistry, vol. 15, Dec. 1972, pp. 1203-1206.
Alaimo The Synthesis of Some 4H-Pyrimido[2,1-b]benzothiazol-4-ones J. Heterocyclic Chemistry, vol. 10, Oct. 1973, pp. 769-772.
Wade, Reaction of 2-Aminobenzazoles with Dimethyl 2-Aminofumarate. Synthesis and Nuclear Magnetic Resonance Spectroscopy of 4-Oxopyrimido[2,1-b]benzazoles, J. Org. Chem., vol. 44, No. 11, 1979 pp. 1811-1816.
Helvetica Chimica Acta., vol. 56, No. 8, 1973, pp. 2981-3004, Koch-Pomeranz et al.
A Convenient Synthesis of 3-Methylthiazolo [3,2-1]benzimidazoles, 3-Benzylthiazolo[3,2-a]benzimidazoles, and 4-Phenylthiazeno[3,2-a}benzimidazoles, Synthesis, Mar. 1976, p. 189, Balasubramanian et al.

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