Process for the manufacture of cystine-containing peptides

Details Process for the manufacture of cystine-containing peptides Process for the manufacture of cystine-containing peptides

1976-05-13

1981-06-02

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

042710685

ABSTRACT:
The invention concerns an improved process for the manufacture of cystine-containing peptides from cysteine-containing aminoacid sequences whose mercapto groups are protected by trityl groups, wherein the S-trityl cysteine-containing sequences are directly oxidized with iodine to yield the cystine disulfide bond.

REFERENCES:
J. Am. Chem. Soc. 87, 4922-4933, (1965).
J. Am. Chem. Soc. 74, 1862-1863, (1952).
J. Am. Chem. Soc. 90, 2677-2681 (1968).
Chem. Ber. 101, 681-693, (1968).
Bull. Chem. Soc. Jap. 37, 433-434, (1964).
J. Org. Chem. 31, 1192-1195, 1966).
J. Am. Chem. Soc. 84, 4789-4794, (1962).

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