Process for the manufacture of budesonide

Details Process for the manufacture of budesonide Process for the manufacture of budesonide

1994-12-16

1996-09-17

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540 61, C07J 7300

Patent

active

055569641

ABSTRACT:
The present invention relates to a novel process for the manufacture of (22 R,S)-16.alpha., 17.alpha.-butylidenedioxy-11.beta., 21-dihydroxypregna-1,4-diene-3,20 dione (I) by reacting 11.beta., 16.alpha., 17.alpha. 21-tetrahydroxypregna-1,4-diene (II) with butanal, CH.sub.3-- CH.sub.2 --CH.sub.2 --CHO, in acetonitrile in presence of p-toluenesulphonic acid as a catalyst.

REFERENCES:
patent: 3077471 (1963-02-01), Fried et al.
patent: 4925933 (1990-05-01), Jakupovic et al.
Linan et al., Chemical Abstracts, vol. 106, 1987 Abstract 675739.
Chem. Abst. vol. 106, No. 9, p. 641, 67573 (Mar. 2, 1987).

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