Process for the manufacture of aromatic cyanides

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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C07C12175

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active

043783198

ABSTRACT:
The invention provides a process for the preparation of ortho- and para-hydroxybenzyl cyanides. The process of the invention comprises the reaction of an aromatic alcohol selected from ortho- and para-hydroxybenzyl alcohols with a cyanide reagent and an ester capable of esterifying the hydroxyl group of the benzyl alcohol.
In a preferred form of the process there is employed a route via the reaction of an ortho- or para-hydroxybenzyl formate with a cyanide reagent preferably selected from sodium and potassium cyanides.

REFERENCES:
patent: 3496211 (1970-02-01), Dexter et al.
patent: 3983160 (1976-09-01), Meyer
patent: 4154757 (1979-05-01), Cooper et al.
patent: 4301088 (1981-11-01), Bernhardt
Schwartz et al., J. Org. Chem., 41 (14), 2502-2503 (1976).
Hayashi et al., Bull. Inst. Chem. Res., Kyoto Univ., 52 (3), 514-518 (1974).

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