Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1986-02-03
1989-05-09
Warren, Charles F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435254, 435136, 435929, 435142, C12P 1702, C12P 740, C12N 114, C12R 177
Patent
active
048289922
ABSTRACT:
The process for the manufacture of the compound of the general structural formula ##STR1## which is a 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) synthase inhibitor and useful as an antihypercholesterolemic agent for the treatment of disease in which the inhibition of cholesterol biosynthesis would be useful, and which is an antifungal agent is disclosed.
REFERENCES:
patent: 3546073 (1970-12-01), Evans et al.
Turner, Fungal Metabolites, Academic Press, 1971, pp. 351-359.
Turner et al., Fungal Metabolites II, Academic Press, 1983, pp. V-VII and 467-476.
Aldridge et al., "Antibiotic 1233A: a Fungal Beta-Lactone", J. Chem. Soc. (C), 1971, vol. 23, pp. 3888-3891.
Del Val Sagrario M.
Fernandez Maria I. M.
Monaghan Richard L.
DiPrima Joseph F.
Marx Irene
Merck & Co. , Inc.
Warren Charles F.
Winokur Melvin
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