Process for the manufacture of 4-methyl-5-hydroxymethyl-imidazol

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D23364

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active

06107490&

ABSTRACT:
A process is provided for the manufacture of 4-lower-alkyl-5-hydroxymethyl-imidazole comprising reacting (4)-lower-alkyl imidazole with formaldehyde in an alkanol solvent having from 2 to 5 carbon atoms in the presence of a solid mild base suspended in the solvent.

REFERENCES:
patent: 4189591 (1980-02-01), Mueller et al.
patent: 4275216 (1981-06-01), Hubert-Brierre

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