Process for the manufacture of 4-(6-bromohexyloxy)-butylbenzene

Details Process for the manufacture of 4-(6-bromohexyloxy)-butylbenzene Process for the manufacture of 4-(6-bromohexyloxy)-butylbenzene

2006-09-26

2006-09-26

Keys, Rosalynd (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

Reexamination Certificate

active

07112701

ABSTRACT:
The present invention relates to an improved process for preparing 4-(6-bromohexyloxy)-butylbenzene by reacting 4-phenylbutanol with 1,6-dibromohexane in the presence of a base and a phase transfer catalyst, wherein 4-phenylbutanol in a diluent is metered into a mixture consisting of 1,6-dibromohexane, a base, a phase transfer catalyst and a diluent, and the use of the 4-(6-bromohexyloxy)-butylbenzene thus prepared for producing salmeterol in a method known per se.

REFERENCES:
patent: 6835857 (2004-12-01), Meyer et al.
patent: 1132373 (2001-09-01), None
patent: 2140800 (1984-12-01), None
patent: WO-9519336 (1995-07-01), None
Jones, Robert M. et al; Mutational Evidence for a Common K antagonist Binding Pocket in the Wild-Type K and Mutant u[K303E] Opioid Receptors; Journal of Medicinal Chemistry; 1998; pp. 4911-4914; vol. 41; No. 25.
Rong, Yajing et al; A New Synthetic Approach to Salmeterol; Synthetic Communications; 1999; pp. 2155-2162; vol. 29; No. 12.

Affiliated with

Also associated with

Rating

Process for the manufacture of 4-(6-bromohexyloxy)-butylbenzene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the manufacture of 4-(6-bromohexyloxy)-butylbenzene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the manufacture of 4-(6-bromohexyloxy)-butylbenzene will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3550039