Process for the manufacture of 3-pyridinium-methyl-cephalosporin

Details Process for the manufacture of 3-pyridinium-methyl-cephalosporin Process for the manufacture of 3-pyridinium-methyl-cephalosporin

1984-05-07

1987-09-08

Warden, Robert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540225, 540227, C07D50146

Patent

active

046925163

ABSTRACT:
Process for the preparation of cephem compounds of the formula ##STR1## wherein R is optionally substituted aminothiazolyl or amino-1,2,4-thiadiazolyl, A is optionally substituted pyridinium, R.sup.1 is hydrogen or methoxy and R.sup.2 are special aliphatic substituents, by a nucleophilic replacement in the substituent in 3-position in the presence of tri-C.sub.1 C.sub.4 -alkyl iodosilane.

REFERENCES:
patent: 4258041 (1981-03-01), O'Callaghan
patent: 4266049 (1981-05-01), Bonjouklian
patent: 4382932 (1983-05-01), Lunn
patent: 4396620 (1983-08-01), Lunn

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