Process for the manufacture of 2-keto-L-gulonic acid

Details Process for the manufacture of 2-keto-L-gulonic acid Process for the manufacture of 2-keto-L-gulonic acid

2006-08-15

2006-08-15

Saucier, Sandra E. (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

C435S041000, C435S132000, C435S252100, C435S252500

Reexamination Certificate

active

07091013

ABSTRACT:
The present invention discloses a process for producing sodium 2-keto-L-gulonate from sorbitol and recovering 2-keto-L-gulonic acid in high recovery yields, by controlled cation exchange treatment of the micro-organism free fermentation broth and/or adjusting PII of said purified fermentation broth, followed by direct crystallisation of 2-keto-L-gulonic acid monohydrate.

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Yuan et al., “Coimmobilization ofGluconobacter oxydansandBacillus cereusfor Bioconversion of 2-Keto-L-gulonic Acid,” Annals New York Academy of Sciences, pp. 628-633—Document No. XP008019736, no pub year.
Urbance et al., “Taxonomic Characterization of Ketogulonigenium Vulgare Gen. Nov., Sp. Nov. And Ketogulonigenium Robustum Sp. Nov., Which Oxidize L-Sorbose to 2-Keto-L-Gulonic Acid,” International Journal of Systematic and Evolutionary Microbiology, vol. 51, pp. 1059-1070 (2001).

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