Process for the manufacture of 1,4-disubstituted bicyclic or tri

Details Process for the manufacture of 1,4-disubstituted bicyclic or tri Process for the manufacture of 1,4-disubstituted bicyclic or tri

1979-07-23

1981-02-03

Mars, Howard T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 6338

Patent

active

042490227

ABSTRACT:
The present invention provides a new process for the manufacture of 1,4-disubstituted bicyclic or tricyclic compounds by reacting a 1,2-bis-cyanomethyl-benzene or 2,3-bis-cyanomethyl-naphthalene with glyoxal in the presence of a base and a solvent as well as new 1,4-disubstituted bicyclic compounds.

REFERENCES:
patent: 3255235 (1966-06-01), Coran
patent: 3709896 (1973-01-01), Frischkorn
patent: 3920734 (1975-11-01), Ichikawa
Beilsteins Handbuch der Organischen Chemie, vol. IX, p. 959 (1926).
Gould, J. Biol. Chem., 130, pp. 407-414 (1939).

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