Process for the large scale production of rabies vaccine

Details Process for the large scale production of rabies vaccine Process for the large scale production of rabies vaccine

1984-10-01

1987-05-12

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

435235, 435236, 435237, 435239, A61K 39205, C12N 700, C12N 708

Patent

active

046649123

ABSTRACT:
In the large-scale production of rabies vaccine a cell stock comprising a VERO cell strain and a liquid nutritive medium containing serum and microcarriers suspended therein is successively passed into biogenerators of increasing volume. The last of the passages is carried out in a biogenerator having a volume of at least 150 liters. The liquid nutritive medium is drawn off at the end of the final passage and replaced with a serum-free liquid nutritive medium. The cell stock is inoculated in the last passage biogenerator with virus which is allowed to develop. The virus is then cultured, withdrawn and filtered. The filtered liquid suspension is then ultrafiltered, with inactivated beta-propiolactone and purified by zonal centrifugation or chromatography.

REFERENCES:
patent: 4347239 (1982-08-01), Bass et al.
patent: 4525349 (1985-06-01), Montagnon et al.
Chemical Abstracts, vol. 97, Abstract No. 11682c, 1982.

Affiliated with

Also associated with

Rating

Process for the large scale production of rabies vaccine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the large scale production of rabies vaccine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the large scale production of rabies vaccine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1801480