Process for the isomerization of asocainol

Details Process for the isomerization of asocainol Process for the isomerization of asocainol

1986-11-17

1988-05-10

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D31300

Patent

active

047436867

ABSTRACT:
A new catalytic process for the isomerization of asocainol isomers at the 6-position which provides an inexpensive, rapid, and simple method for large scale production of the (R,R) isomer of (R,S) asocainol is asocainol. The (R,R) isomer of (R,S) asocainol is treated with small amounts of a salt and an oxidizing agent at an elevated temperature. The compounds and their pharmaceutically acceptable salts are useful as potent antiarrhythmic agents and local anesthetics.

REFERENCES:
patent: 4415495 (1983-11-01), Satzinger et al.
patent: 4649196 (1987-05-01), Herrmann et al.

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